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pentobarbital will minimize the extent or influence of larotrectinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases amounts of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers raise level of toremifene metabolism, lowering the regular-point out focus in ser